Myriam Chaumeil, PhD

Assistant Professor in Residence
Physical Therapy and Rehabilitation Science/Radiology and Biomedical Imaging
+1 415 216-5634

My research program is a direct reflection of my dual education in biology and Magnetic Resonance (MR) physics, and builds upon the synergy between these two fields. I believe that biological discoveries should drive the design of sensitive, specific and clinically translatable MR imaging methods that can improve diagnosis, prognosis and monitoring of therapeutic response. I also trust that thoughtfully applied MR techniques can uncover new biological mechanisms, further our understanding of pathogenic processes and help to identify potential therapeutic targets.

Among all MR methods, the hyperpolarized 13C dissolution dynamic nuclear polarization (DNP) methodology was a thrilling discovery for me, and a perfect fit for my multidisciplinary background. This methodology has been at the center of my research since I move to UCSF as a post-doc. There, I have had the opportunity to learn all aspects of this exciting specialty from internationally recognized scientists, from polarizer hardware to dedicated acquisition schemes. On the biochemistry side, I have developed a high interest in the design and optimization of hyperpolarized probes, from the chemical conceptualization to the requirements for clinical translation.

I am an Assistant Professor in residence in the departments of Physiological Therapy and Rehabilitation Science, and Radiology and Biomedical Imaging at UCSF since 2016. My lab focuses on preclinically developing and biologically validating hyperpolarized 13C methods for in vivo measurement of brain metabolism, in physiological and pathological conditions. We have a particular interest  in expanding the use of MR metabolic imaging to the study of neurodegeneration and neuroinflammation using preclinical models of Multiple Sclerosis (MS), Traumatic Brain Injury and Alzheimer’s disease (AD). While our main field of expertise is preclinical imaging, our ultimate goal is to have a positive impact on healthcare, designing imaging solutions aiming at refining diagnosis, prognosis and therapeutic regimen in a patient-specific way. 

 

Publications: 

Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.

Scientific reports

Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM

Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

NeuroImage. Clinical

Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Tomography : a journal for imaging research

Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB

Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells.

Frontiers in oncology

Viswanath P, Chaumeil MM, Ronen SM

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.

Molecular cancer therapeutics

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM

Magnetic Resonance (MR) Metabolic Imaging in Glioma.

Brain pathology (Zurich, Switzerland)

Chaumeil MM, Lupo JM, Ronen SM

Studies of Metabolism Using (13)C MRS of Hyperpolarized Probes.

Methods in enzymology

Chaumeil MM, Najac C, Ronen SM

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.

Cancer research

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM

Metabolic reprogramming in mutant IDH1 glioma cells.

PloS one

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM

Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

Cancer research

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO

Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.

PloS one

Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma.

Cancer research

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM

Lactate dehydrogenase A silencing in IDH mutant gliomas.

Neuro-oncology

Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG

Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance.

Clinical cancer research : an official journal of the American Association for Cancer Research

Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK

Non-invasive in vivo assessment of IDH1 mutational status in glioma.

Nature communications

Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM

Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla.

Neuro-oncology

Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Chaumeil MM, Valette J, Baligand C, Brouillet E, Hantraye P, Bloch G, Gaura V, Rialland A, Krystkowiak P, Verny C, Damier P, Remy P, Bachoud-Levi AC, Carlier P, Lebon V

Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.

Cancer research

Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM

Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis.

Proceedings of the National Academy of Sciences of the United States of America

Chaumeil MM, Valette J, Guillermier M, Brouillet E, Boumezbeur F, Herard AS, Bloch G, Hantraye P, Lebon V

Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain.

Magnetic resonance in medicine

Valette J, Chaumeil M, Guillermier M, Bloch G, Hantraye P, Lebon V

Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing.

European biophysics journal : EBJ

Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M