Caroline Guglielmetti, PhD

Post-doctoral Scholar
Physical Therapy and Rehabilitation Science
+1 415 206-6973

I am a National Multiple Sclerosis Society (NMSS) postdoctoral scholar in the department of Physical Therapy and Rehabilitation Science at UCSF since June 2016.

My current research focuses on validating hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging (HP 13C MRSI) method for in vivo monitoring of neuroinflammation and specifically oxidative stress in preclinical models of Multiple Sclerosis and Traumatic Brain Injury.
I received my Ph.D. from the University of Antwerp, Belgium. As a Ph.D. student, my research focused on, on the one hand, developing magnetic resonance (MR)-based imaging methods to non-invasively monitor brain changes in preclinical models for Multiple Sclerosis, and on the other hand, developing immune-modulatory therapies in the context of demyelination and associated neuro-inflammation in Multiple Sclerosis.
 
In my free time I participate in the department running club and I love spending the weekends at one of the many festivals and exhibitions in always sunny San Francisco.

Publications: 

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.

Journal of neuroinflammation

Le Blon D, Guglielmetti C, Hoornaert C, Quarta A, Daans J, Dooley D, Lemmens E, Praet J, De Vocht N, Reekmans K, Santermans E, Hens N, Goossens H, Verhoye M, Van der Linden A, Berneman Z, Hendrix S, Ponsaerts P

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.

Glia

Guglielmetti C, Le Blon D, Santermans E, Salas-Perdomo A, Daans J, De Vocht N, Shah D, Hoornaert C, Praet J, Peerlings J, Kara F, Bigot C, Mai Z, Goossens H, Hens N, Hendrix S, Verhoye M, Planas AM, Berneman Z, van der Linden A, Ponsaerts P

Monitoring Blood-Brain Barrier Integrity Following Amyloid-ß Immunotherapy Using Gadolinium-Enhanced MRI in a PDAPP Mouse Model.

Journal of Alzheimer's disease : JAD

Blockx I, Einstein S, Guns PJ, Van Audekerke J, Guglielmetti C, Zago W, Roose D, Verhoye M, Van der Linden A, Bard F

Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.

Scientific reports

Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM

In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants.

Stem cells (Dayton, Ohio)

Hoornaert CJ, Luyckx E, Reekmans K, Dhainaut M, Guglielmetti C, Le Blon D, Dooley D, Fransen E, Daans J, Verbeeck L, Quarta A, De Vocht N, Lemmens E, Goossens H, Van der Linden A, Roobrouck VD, Verfaillie C, Hendrix S, Moser M, Berneman ZN, Ponsaerts P

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy.

NeuroImage

Orije J, Kara F, Guglielmetti C, Praet J, Van der Linden A, Ponsaerts P, Verhoye M

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.

NMR in biomedicine

Praet J, Orije J, Kara F, Guglielmetti C, Santermans E, Daans J, Hens N, Verhoye M, Berneman Z, Ponsaerts P, Van der Linden A

Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis.

Neuroscience and biobehavioral reviews

Praet J, Guglielmetti C, Berneman Z, Van der Linden A, Ponsaerts P

Multimodal imaging of micron-sized iron oxide particles following in vitro and in vivo uptake by stem cells: down to the nanometer scale.

Contrast media & molecular imaging

Roose D, Leroux F, De Vocht N, Guglielmetti C, Pintelon I, Adriaensen D, Ponsaerts P, Van der Linden A, Bals S

Different anesthesia regimes modulate the functional connectivity outcome in mice.

Magnetic resonance in medicine

Jonckers E, Delgado y Palacios R, Shah D, Guglielmetti C, Verhoye M, Van der Linden A

Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain.

NeuroImage

Vande Velde G, Raman Rangarajan J, Vreys R, Guglielmetti C, Dresselaers T, Verhoye M, Van der Linden A, Debyser Z, Baekelandt V, Maes F, Himmelreich U