Lydia Le Page, PhD

Post-doctoral Scholar
Physical Therapy and Rehabilitation Science

I joined the Chaumeil lab at UCSF in June 2017. My research focuses on using imaging to better understand metabolism in neurodegenerative diseases and responses to therapy. More specifically, I am looking at models of traumatic brain injury and aging, using hyperpolarized 13C MR spectroscopy alongside 1H imaging techniques.

I received my PhD from the University of Oxford in the UK, where my research focussed on exploring and non-invasively imaging the metabolic changes that occur in the heart as a result of type 2 diabetes. I studied the effect of a metabolic modulator on the type 2 diabetic heart and showed a reversal of the metabolic and functional dysregulation characteristic of diabetes. I also looked into the effect of hypoxia on the heart, and demonstrated that the differences between acute and chronic hypoxic exposure that can be assessed using hyperpolarized 13C MR.

Following my PhD, I worked as a postdoc at the University of Edinburgh, where I investigated sodium imaging for assessing myocardial health following a heart attack. Most recently I studied low-grade brain tumor metabolism in the Ronen lab at UCSF.

Outside the lab I enjoy running with a postdoc group, and exploring California and beyond.

Publications: 

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.

NMR in biomedicine

Le Page LM, Ball DR, Ball V, Dodd MS, Miller JJ, Heather LC, Tyler DJ

Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.

The Journal of physiology

Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Le Page L, Sousa Fialho Mda L, Shattock MJ, Aasum E, Clarke K, Tyler DJ, Heather LC

Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.

Magnetic resonance in medicine

Ball DR, Rowlands B, Dodd MS, Le Page L, Ball V, Carr CA, Clarke K, Tyler DJ

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

Cardiovascular research

Dodd MS, Ball DR, Schroeder MA, Le Page LM, Atherton HJ, Heather LC, Seymour AM, Ashrafian H, Watkins H, Clarke K, Tyler DJ