Lydia Le Page, PhD

Post-doctoral Scholar
Physical Therapy and Rehabilitation Science

I joined the Chaumeil lab at UCSF in June 2017. My research focuses on using imaging to better understand metabolism in neurodegenerative diseases and responses to therapy. More specifically, I am looking at models of brain inflammation, Alzheimer’s disease and aging, using hyperpolarized 13C MR spectroscopy alongside 1H imaging techniques. I currently hold an Alzheimer’s Association Research fellowship, which is funding my research into brain ketone metabolism in mouse models of Alzheimer’s disease.


I received my PhD from the University of Oxford in the UK, where my research focused on exploring and non-invasively imaging the metabolic changes that occur in the heart as a result of type 2 diabetes. I studied the effect of a metabolic modulator on the type 2 diabetic heart and showed a reversal of the metabolic and functional dysregulation characteristic of diabetes. I also looked into the effect of hypoxia on the heart, and demonstrated that the differences between acute and chronic hypoxic exposure can be visualized using hyperpolarized 13C MR.


Following my PhD, I worked as a postdoc at the University of Edinburgh, where I investigated sodium imaging for assessing myocardial health following a heart attack. Most recently I studied brain tumor metabolism in the Ronen lab at UCSF.

Outside the lab I enjoy running, hiking, and exploring California and beyond. I am also passionate about evidence-based policy and science communication. I am a medical writer for Youreka Science – we make whiteboard videos about exciting science! I was also a 2020 Christine Mirzayan Science and Technology Policy Fellow. For this fellowship I spent three months in Washington DC working at the National Academy of Medicine with the Global Roadmap for Healthy Longevity team who are orchestrating an international, independent, and multidisciplinary initiative that will develop a comprehensive report assessing the challenges presented by population aging.



First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil M, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB

Hyperpolarized 13 C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice.

NMR in biomedicine

Le Page LM, Guglielmetti C, Najac CF, Tiret B, Chaumeil MM

Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13 C magnetic resonance spectroscopy.

NMR in biomedicine

Le Page LM, Rider OJ, Lewis AJ, Noden V, Kerr M, Giles L, Ambrose LJA, Ball V, Mansor L, Heather LC, Tyler DJ

Imaging toxin-induced neuroinflammation in mice using hyperpolarized 13C magnetic resonance spectroscopy


Lydia M Le Page, Caroline Guglielmetti, Chloé Najac, Brice Tiret, Myriam M Chaumeil

In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma.

Scientific reports

Najac C, Radoul M, Le Page LM, Batsios G, Subramani E, Viswanath P, Gillespie AM, Ronen SM

Manganese-Enhanced T1 Mapping in the Myocardium of Normal and Infarcted Hearts

Contrast media & molecular imaging

N. B. Spath, D. M. L. Lilburn, G. A. Gray, L. M. Le Page, G. Papanastasiou, R. J. Lennen, R. L. Janiczek, M. R. Dweck, D. E. Newby, P. C. Yang, M. A. Jansen, and S. I. Semple

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.

NMR in biomedicine

Le Page LM, Ball DR, Ball V, Dodd MS, Miller JJ, Heather LC, Tyler DJ

Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.

The Journal of physiology

Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Le Page L, Sousa Fialho Mda L, Shattock MJ, Aasum E, Clarke K, Tyler DJ, Heather LC

Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.

Magnetic resonance in medicine

Ball DR, Rowlands B, Dodd MS, Le Page L, Ball V, Carr CA, Clarke K, Tyler DJ

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

Cardiovascular research

Dodd MS, Ball DR, Schroeder MA, Le Page LM, Atherton HJ, Heather LC, Seymour AM, Ashrafian H, Watkins H, Clarke K, Tyler DJ