Marina Radoul, PhD

Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma.

Neuro-oncology

Minami N, Hong D, Stevers N, Barger CJ, Radoul M, Hong C, Chen L, Kim Y, Batsios G, Gillespie AM, Pieper RO, Costello JF, Viswanath P, Ronen SM

Preclinical Development of NRTX-1001, an Inhibitory Interneuron Cellular Therapeutic for the Treatment of Chronic Focal Epilepsy (S13.007).

Neurology

Mansi Parekh, Philip Hampel, Marina Radoul, Eric Steven Sevilla, David Traver, Hannah Kim, Nathalie Picard, Andrew Adler, Luis Fuentealba, Jiayin Li, Adrian Bates, Daniel Cherkowsky, Marina Bershteyn, Yves Maury, Myriam Chaumeil, Catherine Priest, Cory Nicholas

Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma.

Metabolites

BIOM-19. METABOLIC ALTERATION INDUCED BY SELECTIVE KNOCK DOWN OF GABPB1L IN U251 CELLS.

Neuro-oncology

Noriaki Minami, Vinay Ayyappan, Nick Stevers, Abigail Molloy, Georgios Batsios, Donghyun Hong, Anne Marie Gillespie, Elavarasan Subramani, Marina Radoul, Joseph Costello, Pavithra Viswanath, Sabrina Ronen

Glutamate is a non-invasive metabolic biomarker of IDH1 mutant glioma response to temozolomide treatment.

Cancer research

Subramani E, Radoul M, Najac C, Batsios G, Molloy AR, Hong D, Gillespie AM, Delos Santos R, Viswanath P, Costello JF, Pieper RO, Ronen SM

MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma.

Theranostics

Molloy AR, Najac C, Viswanath P, Lakhani A, Subramani E, Batsios G, Radoul M, Gillespie AM, Pieper RO, Ronen SM

EXTH-20. HYPERPOLARIZED [2-13C] PYRUVATE TO [5-13C] GLUTAMATE AS BIOMARKERS OF IDH1 MUTANT GLIOMA RESPONSE TO TEMOZOLOMIDE THERAPY.

Neuro-oncology

Elavarasan Subramani, Chloe Najac, Georgios Batsios, Pavithra Viswanath, Marina Radoul, Anne Marie Gillespie, Russell O Pieper, Sabrina Ronen

Abstract 5263: 1H and 13C MRS-based metabolic markers of IDH1 mutant glioma response to temozolomide therapy.

Cancer research

Elavarasan Subramani, Chloe Najac, Georgios Batsios, Pavithra Viswanath, Marina Radoul, Anne Marie Gillespie, Russell O. Pieper, Sabrina M. Ronen

In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma.

Scientific reports

Najac C, Radoul M, Le Page LM, Batsios G, Subramani E, Viswanath P, Gillespie AM, Ronen SM

HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI.

NMR in biomedicine

Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM

EXTH-76. 1H AND HYPERPOLARIZED 13C MRS BIOMARKERS OF IDH1 MUTANT GLIOMA RESPONSE TO TEMOZOLOMIDE THERAPY.

Neuro-oncology

Elavarasan Subramani, Chloe Najac, Georgios Batsios, Pavithra Viswanath, Marina Radoul, Anne Marie Gillespie, Russell Pieper, Sabrina Ronen

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner.

Cancer & metabolism

Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.

Cancer research

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM

METB-14. DOWN-REGULATION OF ACETATE METABOLISM TOWARDS FATTY ACIDS IN IDH1 MUTANT GLIOMA.

Neuro-oncology

Chloe Najac, Marina Radoul, Pavithra Viswanath, Myriam M Chaumeil, Sabrina Ronen

TMOD-20. EARLY DETECTION OF HDAC INHIBITION IN GLIOBLASTOMA USING ADVANCED HYPERPOLARIZED 13C MRSI.

Neuro-oncology

Marina Radoul, Myriam M Chaumeil, Pia Eriksson, Chloe Najac, Pavithra Viswanath, Anne Marie Gillespie, Joydeep Mukherjee, Russell Pieper, Sabrina Ronen

Correction to Thiolate Spin Population of Type I Copper in Azurin Derived from 33S Hyperfine Coupling.

Inorganic chemistry

Cohen MR, Mendelman N, Radoul M, Wilson TD, Savelieff MG, Zimmermann H, Kaminker I, Feintuch A, Lu Y, Goldfarb D

Thiolate Spin Population of Type I Copper in Azurin Derived from 33S Hyperfine Coupling.

Inorganic chemistry

Ramirez Cohen M, Mendelman N, Radoul M, Wilson TD, Savelieff MG, Zimmermann H, Kaminker I, Feintuch A, Lu Y, Goldfarb D

Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

NeuroImage. Clinical

Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM

Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex.

Scientific reports

Radoul M, Lewin L, Cohen B, Oren R, Popov S, Davidov G, Vandsburger MH, Harmelin A, Bitton R, Greneche JM, Neeman M, Zarivach R

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.

Molecular cancer therapeutics

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM

CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS.

Neuro-oncology

Pavithra Viswanath, Jose L. Izquierdo-Garcia, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M. Chaumeil, Michael Blough, H. Artee Luchmann, Samuel Weiss, J. Gregory Cairncross, Joanna J. Phillips, Russell O. Pieper, Sabrina M. Ronen

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.

Cancer research

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM